🧐GLP - 1s或许能解决许多问题，原因可能是人们代谢受损，如在高糖环境下线粒体无法正常使用所有呼吸复合物，但这只是一种可能的机制

🤔GLP - 1s也可能有神奇的效果，但目前尚无确凿证据，且存在很多声称其有神奇效果的动机，但我们应等待更多针对基本健康人群的研究

😕对于基本健康的人，尤其是过度关注外貌或有疑病症的人，使用GLP - 1s的风险可能大于益处，且存在只提及益处而未提及副作用的情况

Published on August 26, 2024 12:34 PM GMT

Motivation for posting:

I read Scott's recent article: https://www.astralcodexten.com/p/why-does-ozempic-cure-all-diseases

And it seems to me that scott isn't considering two points:

GLP-1s might fix a lot of things because people are metabolically compromised (e.g. literally to the point of having mitochondria that are unable to properly use all respiratory complexes due to an odd selection effect in always-high glucose environments) - Or they might be magic, but as of yet there's no conclusive evidence and a lot of incentives to say "magic"You can always come up with alternative mechanisms for why GLP-1s might work, but we should wait for more studies to be done in basically healthy people before we recommend basically healthy people take themIf you are a basically healthy person, especially one that is looks-obsessed or hypochondriac, the risks might outweigh the benefits of GLP-1s... and while nobody is saying the reverse outright, there's a lot of hinting at benefits with no mention of side effects.