本期节目中，Debra Kimless博士和Steve Goldner分享了他们对药用大麻的科学、政策及市场演变的见解。从THC和CBD的区别、人体内的作用机制，到大麻在医疗中的应用及其安全性问题，两位专家进行了深入讨论。他们所在的Pure Green公司致力于提供最安全、有效的药用大麻递送方式，并希望改变人们对大麻的看法，推动其在联邦层面去.schedule，以便更多人能够使用大麻治疗慢性疾病。

🌿 Debra和Steve介绍了他们对医用大麻的兴趣背景及个人经历，探讨了药用大麻的历史及其在医疗中的应用。

🧬 详解了THC、CBD等大麻素在人体内的作用机制，以及大麻的不同使用形式（吸烟、吸入、食用、油剂等）。

🚬 分析了吸烟、吸入、食用等不同摄入方式的优劣，以及THC的安全性问题，包括近期因吸入导致住院和死亡事件的增加。

💊 讨论了CBD和THC的区别，以及Pure Green公司正在进行的大麻素临床研究。

🌱 探讨了大麻作为“入门药物”的观点，以及人们使用大麻的目的和期望。

In this episode, Dr. Debra Kimless and Steve Goldner share their knowledge on the science, policy, and market evolution of medicinal cannabis. We start with the differences between THC and CBD, how they work in the body, and how they act on the brain. We discuss the many potential benefits of using CBD, THC, hemp in the various forms of administration (smoking, vaping, edibles, oils, etc.) as well as some of the safety issues including the recent uptick in incidents of hospitalization and death linked to vaping. Debra and Steve are both involved with the company, Pure Green—Debra the Chief Medical Officer and Steve the founder and CEO—whose aim is to create the safest, most efficacious form of delivery of cannabis. Their bigger mission is to shift the perception of the cannabis plant, garner acceptance of its medicinal benefits, and ultimately get it descheduled on a federal level so more people can access cannabis for a range of chronic ailments.

We discuss:

Debra and Steve’s background reason for their interest in medical cannabis [7:00]; The history of medical use of cannabis [11:15]; How THC, CBD, and other cannabinoids work [16:00]; Hemp—What it is, special uses, and the 2018 farm bill [22:45]; The legal status of CBD, Deb and Steve’s clinical trial, and how CBD differs from THC [30:15]; The safety profile of THC [35:00]; Is marijuana as a gateway drug? [45:30]; Smoking vs. vaping vs. edibles—Benefits, risks, and mechanistic differences [53:30]; Can you build up a tolerance to the effects of THC? [1:15:00]; What do people generally want to get from using marijuana? [1:17:15]; Cannabinoid synthetics [1:22:30]; Efficacy of CBD oils as a sleep aid [1:25:00]; Pure Green Cannabis [1:30:30]; Anecdotal evidence and managing the hype surrounding cannabis in medical treatment [1:38:45]; Aspirations for the future of medicinal cannabis, and the legal challenges that await them [1:45:15]; Descheduling cannabis: A human rights issue [2:04:00] and; More.

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