本期节目邀请了佛罗里达大学药物化学教授、植物源性化合物专家Chris McCurdy博士。我们深入探讨了Kratom（麻叶）的广泛作用，包括提升精力、改善情绪、缓解疼痛以及作为潜在的阿片类替代品。同时，也详细解释了其重要的安全隐患和成瘾性，尤其针对Kratom衍生物和纯化物产品。此外，节目还广泛讨论了植物基化合物的潜在益处与风险，McCurdy博士提供了关于Kratom及其他天然药物的平衡视角，强调了它们对人类健康的希望与潜在的严重风险。

🌿 Kratom（Mitragyna speciosa）作为一种天然植物，因其在提升精力、改善情绪、缓解疼痛以及作为潜在阿片类药物替代品方面的作用而受到广泛关注。然而，专家Chris McCurdy博士强调，Kratom也具有显著的安全隐患和成瘾潜力，特别是其衍生物和纯化物产品。理解其低剂量（偏向兴奋剂）和高剂量（偏向镇痛镇静）下的不同效果至关重要，这需要用户对产品类型和剂量有清晰的认知。

⚖️ 文章区分了传统Kratom叶片与高度浓缩的Kratom衍生物/纯化物产品。后者因其更高的生物碱浓度，带来的风险和成瘾性也随之增加。用户在选择和使用Kratom产品时，需要仔细理解产品标签，注意其成分和浓度，以避免不必要的健康风险。

🔗 Kratom的使用，特别是长期或高剂量摄入，可能导致身体依赖，其戒断症状与阿片类药物有相似之处。尽管Kratom可能被用作阿片类药物依赖的辅助治疗，但其自身的成瘾性不容忽视。此外，Kratom与酒精或其他药物合用时，可能增加呼吸抑制等严重不良反应的风险。

🔬 探讨Kratom也延伸至对更广泛的植物基化合物的讨论，强调了自然界中蕴藏的巨大药用潜力。然而，现代药物开发有时与自然来源脱节，过高的产品浓度可能放大风险。McCurdy博士的观点在于，需要一种平衡的视角，既认识到天然产物对人类健康的巨大希望，也审慎评估其潜在的严重风险，以实现安全有效的利用。

My guest is Dr. Chris McCurdy, PhD, FAAPS, professor of medicinal chemistry at the University of Florida and a world expert on the pharmacology of kratom and other plant-derived medicinal compounds. We discuss kratom’s wide-ranging effects, including its use for boosting energy, enhancing mood, managing pain and as a potential opioid substitute, while also explaining its critical safety concerns and addictive potential, especially for kratom-derived/isolate products. We also discuss plant-based compounds more generally for their potential benefits and risks. Dr. McCurdy offers a balanced perspective on kratom and other plant-based and naturally occurring medicinal compounds, highlighting and contrasting their promise for human health with potential serious risks.

Read the episode show notes at hubermanlab.com.

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Timestamps

00:00:00 Chris McCurdy

00:02:51 Kratom (Mitragyna speciosa), Origin, Effects, Low vs High Doses

00:07:19 Sponsors: David Protein & Eight Sleep

00:10:07 Kratom, Traditional Use vs Commercial Kratom Products, Absorption

00:17:00 Kratom Products, Serving Size, Kids; Semi-Synthetics; Tool: Understand Kratom Product Labels

00:23:16 Kratom Products & Various Desired Effects; Physical Dependence

00:32:53 Different Kratom Usage Patterns, Opioid Dependence

00:36:59 Alkaloid Compounds, Nitrogen, Nicotine; Animals & Self-Experimentation

00:47:47 Sponsors: AG1 & ROKA

00:51:05 Medicine Development, Disconnection from Nature, Product Concentrations

00:59:00 Alkaloids & Natural Products, Opium Poppy, Coca Leaf, Tool: Kratom Leaf vs Extracts (Kratom-Derived/Kratom Isolates)

01:09:06 Is It Safe for Kids to Consume Kratom Products?

01:12:19 Kratom, Energy, Mood & Pain Management, Dose; Caffeine

01:16:56 Respiratory Depression & Kratom Products

01:20:16 Sponsor: Function

01:22:04 Kratom Leaf vs Derivatives, FDA Regulations, Usage Guidelines

01:26:59 Kratom, Alcohol Consumption, Respiratory Failure?

01:29:09 Kratom Alkaloids, Mood & Stimulant Effects, Multiple Pathways for Pain Relief

01:38:17 Plant Alkaloids & Chemical Defense, Kratom & Antifungal Alkaloids; Geckos

01:44:35 White, Red & Brown Vein Kratom, Leaf Processing; Terpenes

01:51:08 Kratom as an Anti-Depressant?; Discontinuing Kratom Use, Opioid Use

01:58:03 Kratom, Drug Interactions & Seizure, Opioids

02:01:51 Cacao Beans, Chocolate

02:09:34 Coca-Cola, Coca Plant & Cocaine, History of Soft Drinks

02:19:49 Career Journey, Pharmacy, Chemistry & Education, Lobelia

02:28:44 Nicotine; Natural Products & Career Journey, Salvia divinorum, Kratom

02:40:22 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter

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