TechCrunch News 03月04日
On a quest to revive the woolly mammoth, Colossal Biosciences has created a woolly mouse
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Colossal Biosciences公司以其在2028年前复活猛犸象的宏伟目标而闻名,近日声称取得了稳步进展。该公司通过基因工程改造小鼠,使其拥有类似猛犸象的毛发,以此作为证据。科学家们找到了小鼠体内与猛犸象基因对应的版本,并利用CRISPR技术编辑小鼠胚胎,再将这些胚胎植入代孕小鼠体内。实验结果表明,这些“多毛小鼠”的毛发在颜色、质地和厚度上都与猛犸象的特征相似。Colossal Biosciences相信,这种多毛的皮毛将使基因工程改造的小鼠能够在寒冷气候中生存。公司还计划复活塔斯马尼亚虎和渡渡鸟。尽管前景光明,但仍面临诸多挑战,如需获得伦理审查批准,以及验证这些基因是否能真正提高猛犸象对寒冷环境的适应能力。

🧬Colossal Biosciences公司利用CRISPR技术,通过基因编辑小鼠胚胎,成功培育出具有类似猛犸象毛发特征的“多毛小鼠”,这是该公司复活猛犸象计划的重要一步。

🐘Colossal Biosciences的复活猛犸象方法包括绘制已灭绝的猛犸象的完整基因组,并将其与现存关系最近的亚洲象进行比较,以找出关键的基因差异。

🔬在进行寒冷耐受性实验之前,Colossal Biosciences必须首先获得机构动物护理和使用委员会(IACUC)的批准,以确保动物研究的伦理性和人道性。

💰Colossal Biosciences公司在一月份宣布完成2亿美元融资,估值达到102亿美元,这表明投资者对其技术创新速度和复活灭绝动物的潜力充满信心。

⚠️尽管Colossal Biosciences取得了进展,但UC Davis的古生物学教授David Gold指出,大象和猛犸象的DNA之间存在数百个差异,因此复活猛犸象仍然面临许多技术难题。

Colossal Biosciences, known for its outlandish goal to resurrect the woolly mammoth by 2028, is claiming steady progress. It’s evidence: Genetically engineering mice to have mammoth-like fur.

To engineer the woolly mouse, the company’s scientists found mouse versions of mammoth genes and then used CRISPR to edit mice embryos, Dr. Beth Shapiro, chief science officer at Colossal, told TechCrunch. Then, those embryos were implanted into surrogate mouse moms.

The company says that the woolly mice’s fur is of a color, texture and thickness that resembles a mammoth’s traits.

Colossal Biosciences believes the woolly coat will enable its genetically-engineered mice to survive in cold climates. Still, the company must first obtain approval from the Institutional Animal Care and Use Committee (IACUC), which ensures ethical and humane animal research, before conducting such experiments.

Shapiro said the company needs to test the engineered mice’s cold tolerance to validate if those genes would improve the mammoth’s adaptation to cold environments.

Colossal’s approach to bringing back the mammoth involves mapping the entire genome of an extinct woolly mammoth and comparing it with its closest living relative, the Asian Elephant.

Investors have been impressed with the speed at which the company is creating technologies, Ben Lamm, Colossal Biosciences’ co-founder and CEO, told TechCrunch when the company announced a $200 million round at a $10.2 billion valuation in January.

In addition to working on a woolly mammoth, the company aims to bring back the Tasmanian tiger and the dodo bird.  

But that 2028 goal might not be realistic. According to David Gold, a professor of Paleobiology at UC Davis, producing multiple mutations in mice is hard, but it’s not nearly as difficult as creating a woolly mammoth.

“It is exciting to see the mice produce a mammoth-like coat. But there are hundreds of differences between the DNA of an elephant and a mammoth, so there is a long way to go,” Gold said. He added that while he believes that it will be possible to eventually re-create the woolly mammoth, there are a lot of technical hurdles ahead.

Still, Lamm calls Colossal’s creation of the woolly mouse a “watershed moment” for the company’s de-extinction mission.

“The animals were born healthy, and they had the exact phenotypes that we predicted,” Lamm said. “The only thing that was unintended was the adorability factor. They are just way cuter than we anticipated.”

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Colossal Biosciences 猛犸象 基因工程 CRISPR 灭绝动物
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