Fortune | FORTUNE 2024年10月12日
Getting good-quality sleep as you age is key for a healthy brain. These 4 strategies can help
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文章探讨了老年人睡眠问题,指出随着年龄增长睡眠会变短且更碎片化,多种因素会影响睡眠及脑健康。研究者发现睡眠与认知功能相关,还提到了改善睡眠的策略及睡眠问题的原因等。

🎈随着年龄增长,睡眠会变得更短且碎片化,在慢波和快速眼动睡眠中花费的时间减少,且未诊断或未治疗的睡眠呼吸暂停等也会影响脑健康。

💤睡眠对脑健康有重要作用,睡眠中断可能导致阿尔茨海默病相关蛋白积累,不良睡眠会导致炎症和代谢功能障碍,与认知下降或痴呆有关。

👩‍🔬Stone的研究表明,女性可能对睡眠中断更敏感,且睡眠质量差的人更易患痴呆。参与者佩戴活动记录仪进行研究,发现睡眠碎片化及24小时睡眠-觉醒节律较弱的人,认知障碍的几率更大。

📋老年人睡眠受多种因素影响,如呼吸障碍、慢性胃灼热、关节炎、膀胱过度活动、神经退行性疾病及药物副作用等。

💡改善睡眠的策略包括与健康提供者合作解决睡眠问题、考虑认知行为疗法、不回避与医生谈论睡眠问题、将睡眠健康作为优先事项。

Age-related sleep disruptionsWhile we don’t need as much sleep as we did as teenagers, most older people still need about seven hours of good-quality sleep each night, according to Katie Stone, an epidemiologist and sleep researcher at California Pacific Medical Center and the University of California, San Francisco. However, as we age, our sleep tends to become shorter and more fragmented, with less time is spent in slow-wave and rapid eye movement (REM) sleep, Stone and other sleep researchers found. Additionally, other age-related sleep disruptions—including undiagnosed or untreated sleep apnea, as well as conditions such as depression and anxiety—can have a real impact on our brain health.Sleep for better brain health“Evidence suggests that sleep plays a role in clearing Alzheimer’s-linked proteins from the brain,” said Stone. “In the presence of sleep disruption, those plaques, like beta amyloid, can accumulate and that’s an early sign that somebody may be progressing toward Alzheimer’s disease or dementia.” Additionally, poor sleep contributes to inflammation and metabolic dysfunction, which also are linked to cognitive decline or dementia.Researchers are growing more comfortable directly linking poor sleep health with cognitive decline. “The evidence is growing that it could be that it very well be causal,” Stone said. What hasn’t been firmly established is whether treating sleep problems can effectively slow that down. Researchers are on the cusp of learning whether treating poor sleep can not only prevent or delay decline in cognitive function but also reduce falls or other negative health effects that happen as we get older. Her current research shows that getting more consolidated sleep, and having fewer awakenings, is better for the brain.Stone, who has been researching sleep and older adults for decades, has also also found that women may be more sensitive to sleep disruptions than men. Women tend to have more complaints about sleep, and insomnia is more common in women.“Insomnia is really more of a subjective report of sleep problems with symptoms that are disturbing to the individual during the day. It’s not like an objective test that you do similar to sleep apnea,” Stone explained. Other researchers are investigating possible hormonal links to sleep quality and gender differences in sleep health.Stone and her team studied 820 older adults who were enrolled in the Study of Muscle, Mobility and Aging (SOMMA) for changes in executive function and in global tests of cognition. Participants wore actigraphs—small wristwatch-size monitors—for a week, to measure variables like total sleep time and sleep efficiency. They found that people with greater sleep fragmentation, as well as weaker 24-hour sleep-wake rhythms, had significantly greater odds of cognitive impairment. In this analysis, total sleep time had no effect at all on cognitive test performance.In a prior study, Stone and colleagues reported that over five years of follow-up, people who did not have dementia at the start of the study, but had poorer sleep quality, were more likely to develop dementia over the long term. There are many reasons older adults might have disrupted sleep, according to gerontologist Dr. Leslie Kernisan, a clinical instructor in the UCSF division of geriatrics, and host of the Better Health While Aging podcast. Among them: breathing disorders, like sleep apnea or COPD; chronic heartburn or gastric reflux; arthritis; overactive bladder; neurodegenerative diseases like Alzheimer’s or Parkinson’s; and medication side effects, which can be a huge culprit.Nearly 90% of people over 65 take at least one prescription daily, and more than a third (36%) are on five or more prescriptions. Many of these medications can impact sleep quality. It becomes a cycle—someone is prescribed sleep medications to get them through the night, which may have side effects like residual daytime grogginess. Then, they nap during the day, which then makes it more difficult to fall asleep at night. Certain sleep medications themselves can also increase risk of dementia by as much as 79%, according to another UCSF study.In addition to what is now standard advice for better sleep, such as turning off electronic devices and making your bedroom as comfortable and dark as possible, Stone also suggests these strategies:1. Work with a health provider to address sleep problems rather than just self-medicatingWhile some people swear by supplements like melatonin or use combination pain relievers/sleep aids, she says they often don’t work all that well and can lead to other issues, like increased risk of falls when getting out of bed. We also still don’t know some of the long term effects of using certain medications, and they could be harmful in the long term.2. Consider cognitive behavioral therapy for insomnia symptomsFor people who stay on cognitive behavioral therapy over the long term, It’s more effective and tends to have a more lasting effect than medications. It’s the first line of treatment for insomnia recommended by the American College of Physicians and other health organizations.3. Don’t shy away from talking to your healthcare provider about your sleep issuesMany sleep disorders, like sleep apnea, can be diagnosed by your doctor and treated without medication.4. Make sleep health a prioritySleep is just as critical to older people as a balanced diet and regular exercise, Stone said. It may get overlooked as an inevitable negative aspect of aging, but it’s an equally important pillar of health, and you can do something about it.View the new Fortune 50 Best Places to Live for Families list. Discover the 2024 top destinations across the U.S. for multigenerational families to live, thrive, and find community. Explore the list.

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老年人睡眠 脑健康 睡眠问题 改善策略 认知功能
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