本期节目中，预防心脏病专家Ethan Weiss深入探讨了心血管疾病以及生长激素和IGF在疾病中的作用。他不仅详细讲解了冠心病综合征、支架置放的复杂细节，还分享了如何利用钙评分和CT血管造影结果来治疗患者。此外，Ethan还讲述了他如何通过研究性别差异在血栓形成中的作用，进而投身内分泌学领域，并揭示了生长激素和IGF对肝脏、大脑及人类寿命的影响。

🎯 Ethan Weiss介绍了急性冠状动脉综合征和支架置放的复杂性，以及他如何利用钙评分和CT血管造影结果来指导治疗。

🔬 Ethan探讨了冠状动脉疾病和心肌梗死的临床定义，以及它们引起的急性事件的原因。

🚑 Ethan分享了当患者出现ST段抬高型心肌梗死（STEMI）时，急诊室的处理流程。

💉 他详细讨论了治疗急性与慢性冠状动脉疾病的方案，包括历史、争议以及重要的区别。

🧬 Ethan讲述了生长激素和IGF在慢性疾病和癌症中的作用，以及它们是否能够促进长寿的可能性。

In this episode, Ethan Weiss, Hopkins trained preventative cardiologist at UCSF, discusses two topics that on the surface may seem unrelated which is cardiovascular disease, and the role of growth hormone and IGF in disease. Ethan provides a masterclass in everything from acute coronary syndrome to all of the complex nuances around stent placement, as well as how calcium scores and results from CT angiograms shape his treatment of patients. He also shares how his idea to study the sex differences in blood clotting as it relates to coronary disease lead him to pursue the field of endocrinology, and specifically what he found with respect to the effect of growth hormone and IGF on the liver, the brain, and overall human longevity. 

We discuss:

Mutual love for hockey [7:15]; Ethan’s background and interest in cardiology [13:15]; Clinical definitions of a heart attack, clotting, and plaque: What causes the acute event? [24:15]; Defining coronary disease and myocardial infarction: The evolving nomenclature [32:00];  What happens when someone comes to the ER with a STEMI (ST elevation myocardial infarction)? [47:15]; Stents [54:45]; Treatment protocol for both acute and chronic coronary artery disease: History, controversy, and important distinctions [1:06:30]; Using stents to treat stable angina: What we learned from the COURAGE AND ORBITA trials [1:15:30]; The “art” of longevity: The challenge of preventative medicine and understanding risk [1:31:45]; Understanding CAC scores, and CT angiogram results [1:40:15]; How sex differences in clotting and heart disease got Ethan interested in growth hormone and IGF [2:01:00]; Impact of growth hormone on the liver [2:07:00]; Growth hormone and insulin sensitivity [2:18:00]; The role of GH and IGF on chronic disease and cancer [2:23:30]; Will taking growth hormone promote longevity? [2:32:30]; GH and IGF as a treatment for early stage dementia? [2:34:30]; What happens to IGF while fasting and what about fasting improves longevity?  [2:35:15]; The importance of becoming scientifically literate and making science more exciting for future generations [2:38:30]; Ethan’s new company: Keyto [2:43:45]; and More.

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