本期“Ask Me Anything”节目中，Peter和Bob深入探讨了尼古丁这一既复杂又有趣的分子，它对大脑和身体都有影响。他们分析了研究结果显示尼古丁的认知益处和可能的减肥效果，讨论了尼古丁替代疗法作为戒烟技巧，并详细介绍了各种给药途径、剂量和安全性的信息。最后，他们探究了吸烟者患严重COVID-19病例可能性较低的引人注目的观察结果。

🧠 尼古丁的认知益处：节目概述了关于尼古丁对认知有益影响的研究文献，探讨了尼古丁在哪些方面对认知有最积极的影响，并分析了可能带来这些益处的机制。

🚬 尼古丁替代疗法（NRT）：讨论了用于戒烟的尼古丁替代疗法产品、方案以及文献回顾，为想要戒烟的人提供了实用的信息和指导。

🦠 吸烟与COVID-19的关系：分析了吸烟似乎能够预防COVID-19的观察结果，这一反直觉的发现为疫情研究提供了新的视角。

💉 尼古丁替代疗法的详细分析：节目详细介绍了尼古丁替代疗法的给药途径、剂量和安全性，为寻求戒烟方法的人提供了全面的信息。

🤔 尼古丁的结论性思考：最后，节目对尼古丁的使用案例、成瘾性质等问题进行了总结性思考，为听众提供了深入的理解。

In this “Ask Me Anything” (AMA) episode, Peter and Bob dive deep into nicotine, a complicated and interesting molecule that has effects on both the brain and the body. They analyze the results of the studies that describe nicotine’s cognitive benefits and potential for inducing weight loss. They talk about a smoking cessation technique called nicotine replacement therapy and give a full breakdown of the various routes of administration, dosing, and safety. Finally, they explore the fascinating and counterintuitive observation that cigarette smokers are less likely to get a severe case of COVID-19. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #23 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss:

How Peter first became interested in the potential benefits of nicotine [1:15]; Untangling nicotine from tobacco [6:00]; Nicotine replacement therapy (NRT) for quitting smoking: products, protocols, and a review of the literature [9:30]; The cognitive benefits of nicotine: Overview of the literature [15:50]; Where nicotine has the most positive impact on cognition [30:30]; Possible mechanisms conferring the benefits of nicotine [37:00]; How modafinil and other nootropics compare to nicotine [47:15]; How nicotine may induce weight loss [54:00]; Relationship between smoking and COVID-19: Analyzing the observation that smoking appears protective against COVID-19 [1:01:45]; Breakdown of the various nicotine replacement therapies: route of administration, dosing, and safety [1:11:30]; Concluding thoughts on nicotine: use cases, addictive properties, and more [1:19:45]; and More.

Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/ama23  Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.