本期AMA节目中，Peter和Bob探讨了心肺健康、肌肉质量与力量对长寿的益处。他们深入研究了随着年龄增长，健康水平下降导致的发病率和死亡风险迅速上升的文献。同时，他们还分析了心肺健康、肌肉质量与力量之间的相对贡献，并讨论了禁食对肌肉质量的影响及其潜在的权衡。

🏃‍♂️ 心肺健康与VO2 max的关系：节目讨论了VO2 max与心肺健康之间的关联，以及如何通过提高VO2 max来改善心肺健康。

📉 肌肉质量与力量随年龄下降：分析了肌肉质量、功能随年龄增长而减少的情况，以及如何定义、测量肌肉减少症（sarcopenia）的临界点。

💪 肌肉大小与力量的影响：探讨了肌肉大小与力量哪个对死亡风险有更大的影响，以及如何评估心肺健康和肌肉力量共同对死亡风险的累积影响。

🤕 跌倒致死率上升与阿尔茨海默症：调查了跌倒致死率上升的现象，以及阿尔茨海默症可能扮演的角色。

🥗 禁食对肌肉质量的影响：讨论了禁食对肌肉质量的影响，以及需要考虑的潜在权衡。

🧍‍♂️ 维持肌肉质量与力量的重要性：强调了随着年龄增长，努力维持肌肉质量与力量的重要性。

In this “Ask Me Anything” (AMA) episode, Peter and Bob discuss the longevity benefits from greater cardiorespiratory fitness (CRF) and greater muscle mass and strength. Conversely, they dive deep into the literature showing a rapid increase in morbidity and mortality risk as fitness levels decline with age. They also try to tease out the relative contributions of CRF, muscle mass, and strength. Additionally, they discuss the impact of fasting on muscle mass, the potential tradeoffs to consider, and finish by discussing why it’s critical to maximize your fitness level. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #27 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss:

VO2 max and its association with cardiorespiratory fitness [2:45]; Changing mortality risk based on VO2 max and cardiorespiratory fitness [7:45]; The profound impact of improving cardiorespiratory fitness [15:15]; Muscle mass, function, and loss with aging: how it’s defined, measured, and the cutoff points for sarcopenia [25:00]; Increasing mortality risk associated with declining muscle mass and strength [40:00]; Muscle size vs. strength—which has the bigger impact on mortality risk? [58:00]; Evaluating the cumulative impact of cardiorespiratory fitness and muscular strength on mortality risk when put together [1:03:30]; Investigating the rising incidence in deaths from falls, and what role Alzheimer’s disease might play [1:09:00]; The impact of fasting on muscle mass and the potential tradeoffs to consider [1:14:30]; The critical importance of working to maintain muscle mass and strength as we age [1:20:30]; and More.

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