本期节目邀请了健身教育家德雷克，他深入探讨了外源性分子对男性和女性健康的影响，涵盖了睾酮、DHT、DHEA、孕酮、克罗米芬（克罗米芬）、hCG 和各种肽，以及 FDA 对肽使用的最新更新。此外，他还讨论了通过抑制肌生成素的卵泡抑素基因治疗和补充剂来增加肌肉质量的最新炒作。他还讨论了健美运动员用于减脂同时保持肌肉的各种策略，包括对减肥药物的见解。

👨‍⚕️ **睾酮和 DHT：** 睾酮和 DHT 的作用机制、肌肉生长的调节以及对男性和女性特征的影响。睾酮是男性性激素的主要类型，它可以促进肌肉生长、骨骼生长和红细胞生成。DHT 则是睾酮的代谢产物，它在男性性发育和脱发中发挥重要作用。在女性中，睾酮水平较低，但它仍然对肌肉生长和性欲等方面起着重要作用。

👩‍⚕️ **女性中的 TRT：** 探索女性使用睾酮的复杂性和潜在风险。TRT（睾酮替代疗法）通常用于治疗男性低睾酮症，但近年来，一些女性也开始使用 TRT 来改善肌肉生长、性欲和能量水平。然而，女性使用 TRT 存在着潜在的风险，例如男性化特征、心血管疾病风险增加以及生育问题。因此，女性在考虑使用 TRT 之前，应该咨询医生，并权衡利弊。

👩‍⚕️ **DHEA 补充剂：** 探索 DHEA 对女性的益处和风险，以及男性和女性的不同影响。DHEA 是一种在体内自然产生的激素，它在青春期和成年早期发挥重要作用。随着年龄的增长，DHEA 水平会逐渐下降。DHEA 补充剂被认为可以改善情绪、认知功能和免疫力。然而，DHEA 补充剂也存在潜在的风险，例如心血管疾病风险增加和某些癌症的风险增加。

💊 **孕酮：** 探索孕酮在男性和女性中的作用，补充剂的优缺点，量身定制剂量的重要性等等。孕酮是一种女性性激素，它在月经周期、妊娠和生育中发挥重要作用。男性也产生少量孕酮，它在精子生成和性欲中发挥作用。孕酮补充剂可以用于治疗月经不调、不孕症和更年期症状。然而，孕酮补充剂也存在潜在的风险，例如体重增加、情绪波动和血栓形成风险增加。

💪 **卵泡抑素基因治疗和肌生成素抑制：** 探索通过卵泡抑素基因治疗和补充剂来增加肌肉质量的最新炒作，人类和动物数据，以及更多研究的必要性。卵泡抑素是一种蛋白质，它可以抑制肌生成素，肌生成素是一种抑制肌肉生长的蛋白质。卵泡抑素基因治疗和补充剂被认为可以增加肌肉质量，但目前的研究还处于早期阶段，需要更多的数据来确定其安全性有效性。

📉 **减脂方法：** 探索健美运动员用于减脂同时保持肌肉的各种策略，包括对减肥药物的见解。健美运动员通常使用多种策略来减脂，例如热量限制、有氧运动和阻力训练。一些健美运动员还会使用减肥药物，例如 L-肉碱和西布曲明，但这些药物的安全性有效性尚存争议。

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Derek is a fitness educator, the entrepreneur behind More Plates More Dates, and an expert in exogenous molecules commonly used and misused by bodybuilders and athletes. In this episode, Derek returns to the podcast to explore the impact of exogenous molecules on male and female health. He covers testosterone, DHT, DHEA, progesterone, clomiphene (Clomid), hCG, and various peptides, alongside updates from the FDA affecting peptide use. Additionally, he addresses the recent hype around increasing muscle mass through myostatin inhibition via follistatin gene therapy and supplementation. Additionally, Derek discusses the various strategies that bodybuilders use for losing fat while preserving muscle, including insights on weight loss drugs.

We discuss:

Testosterone and DHT: mechanisms of action, regulation of muscle growth, and influence on male and female characteristics [2:15]; TRT in women: the complexities and potential risks associated with testosterone use in women [9:00]; DHEA supplementation: exploring the benefits and risks for women, and the differing effects on men vs. women [22:00]; The role of progesterone in both men and women, pros and cons of supplementation, the importance of tailored doses, and more [28:00]; Measuring levels of free testosterone [37:15]; The trend towards earlier interest in TRT, and the risks of underground sources of testosterone [42:00]; The complexities and considerations surrounding the use of Clomid, E-Clomid, and hCG in TRT [46:00]; Low testosterone: diagnosis, potential causes, treatment options, and other considerations [53:45]; Growth hormone-releasing peptides: rationale and implications of the recent FDA categorization as high-risk substances [1:03:45]; Follistatin gene therapy and myostatin inhibition for increasing muscle mass: the recent hype online, human and animal data, and the need for more research [1:14:45]; Simple tips for lowering calorie intake and losing fat [1:32:30]; Methods of sustainable fat loss with muscle preservation: insights gleaned from bodybuilders [1:40:00]; Could prolonged fasting impact testosterone levels? [1:55:30]; High-protein ice cream [1:57:00]; Exploring fat loss supplements and drugs: L-carnitine, yohimbine, and more [2:02:15]; Potential remedies for individuals experiencing metabolic dysfunction due to hypercortisolemia [2:12:30]; The cornerstones of body composition improvement remain nutrition and exercise, even in the presence of exogenous testosterone [2:19:15]; The importance of approaching health advice found online with a critical eye and a healthy dose of skepticism [2:23:30]; and More.

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