Huberman Lab 2024年07月17日
Dr. Matthew Johnson: Psychedelics for Treating Mental Disorders
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本次节目邀请了约翰霍普金斯医学院精神病学和行为科学教授马修·约翰逊博士,讨论了迷幻药物如赛洛西宾、MDMA、死藤水、DMT和LSD的生物特性及临床试验应用。约翰逊博士介绍了他的实验室中进行的临床试验,这些试验揭示了这些化合物在治疗抑郁症、成瘾、创伤、饮食障碍、ADHD等精神障碍中的潜力,并详细描述了实验流程和最佳临床结果的条件。同时,他也解释了迷幻药物的一些潜在危险和常见误区。

🧬 迷幻药物的生物学基础:节目探讨了迷幻药物如何影响大脑中的血清素和多巴胺系统,以及它们如何改变感知和时间空间的感知。

🔬 临床试验揭秘:约翰逊博士详细介绍了实验室中的迷幻药物实验,从开始到结束,包括为达到最佳临床结果所需的条件。

🚧 潜在风险与误区:讨论了迷幻药物使用中的一些潜在危险,如闪回、某些人群和年龄组使用迷幻药物的高风险,以及围绕迷幻药物的法律法规和制药行业的发展。

💡 精神病学的新方向:约翰逊博士分享了迷幻药物研究如何可能在未来几年内设定精神病学药物治疗的新方向,以及如何将这些强大化合物融入其他精神治疗中。

🧩 未来趋势与研究文化:节目最后探讨了迷幻药物研究的趋势变化,学术文化的发展,以及如何参与临床试验和在线调查研究。

This episode I discuss medical research on psychedelic compounds with Dr. Matthew Johnson, Professor of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine. We discuss the biology and medical clinical-trial uses of psilocybin, MDMA, ayahuasca, DMT, and LSD. Dr. Johnson teaches us what the clinical trials in his lab are revealing about the potential these compounds hold for the treatment of depression, addiction, trauma, eating disorders, ADHD, and other disorders of the mind. Dr. Johnson describes a typical psychedelic experiment in his laboratory, start to finish, including the conditions for optimal clinical outcomes. And he explains some of the potential hazards and common misconceptions and pitfalls related to psychedelic medicine. Dr. Johnson explains flashbacks, the heightened risks of certain people and age groups using psychedelics and the ever evolving legal and pharmaceutical industry landscape surrounding psychedelics. Dr. Johnson also explains how the scientific study of psychedelics is likely to set the trajectory of psychiatric medicine in the years to come. Dr. Johnson is among a small handful of researchers who have pioneered the clinical study of these powerful compounds. He has unprecedented insight into how they can be woven into other psychiatric treatments, changing ones sense of self and of reality.

For the full show notes, visit hubermanlab.com.

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Timestamps

(00:00:00) Introducing Dr. Matthew Johnson

(00:02:27) Sponsors: AG1, LMNT

(00:06:40) ‘Psychedelics’ Defined

(00:14:09) Hallucinations, Synesthesia, Altered Space-Time Perception

(00:19:56) Serotonin & Dopamine 

(00:23:50) Ketamine & Glutamate 

(00:28:00) An Example Psychedelic Experiment

(00:37:30) ‘Letting Go’ with Psychedelics

(00:44:10) Our Mind’s Eye

(00:48:00) Redefining Your Sense of Self 

(00:58:56) Exporting Psychedelic Learnings to Daily Life

(01:04:36) Flashbacks

(01:12:10) Ayahuasca, & ASMR, Kundalini Breathing

(01:15:54) MDMA, DMT

(01:26:00) Dangers of Psychedelics, Bad Trips, Long-Lasting Psychosis

(01:38:15) Micro-Dosing

(01:56:45) Risks for Kids, Adolescents & Teenagers; Future Clinical Trials

(02:03:40) Legal Status: Decriminalization vs. Legalization vs. Regulation

(02:18:35) Psychedelics for Treating Concussion & Traumatic Brain Injury 

(02:27:45) Shifting Trends in Psychedelic Research, Academic Culture

(02:44:23) Participating in a Clinical Trial, Online Survey Studies, Breathwork 

(02:50:38) Conclusions, Subscribing & Supporting the HLP, Supplements

Title Card Photo Credit: Mike Blabac

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相关标签

迷幻药物 精神病学 临床试验 治疗潜力 风险与挑战
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