本期节目深入探讨了尼古丁对大脑和身体的影响，包括它如何增强注意力、集中力和警觉性，提高血压和新陈代谢，以及减少食欲。节目还解释了尼古丁如何增加多巴胺、去甲肾上腺素和乙酰胆碱等神经化学物质的活性，并激活交感神经（促进警觉）神经回路。此外，节目还探讨了常见的尼古丁传递方式，例如香烟、电子烟、口香糖和鼻烟，以及它们如何创造独特的体验，以及它们如何（但尼古丁本身不会）导致癌症和其他不良健康影响。最后，节目还介绍了基于科学的工具来永久戒烟，包括同行评审的临床催眠工具、抗抑郁药和替代尼古丁替代疗法（贴片、含片、口香糖等）。

😊 **尼古丁对大脑和身体的影响：** 尼古丁是一种强大的物质，它能增强注意力、集中力和警觉性，提高血压和新陈代谢，并减少食欲。这些效果是由于尼古丁增加多巴胺、去甲肾上腺素和乙酰胆碱等神经化学物质的活性，以及激活交感神经（促进警觉）神经回路造成的。

🧐 **尼古丁传递方式：** 尼古丁可以通过多种方式传递，包括香烟、电子烟、口香糖和鼻烟。每种传递方式都会创造独特的体验，但它们（但尼古丁本身不会）会导致癌症和其他不良健康影响。

💪 **戒烟策略：** 对于想要戒烟的人来说，有许多基于科学的工具可以帮助他们。这些工具包括同行评审的临床催眠工具、抗抑郁药和替代尼古丁替代疗法（贴片、含片、口香糖等）。

🧠 **尼古丁对大脑的影响：** 尼古丁会影响大脑的多个区域，包括与注意力、记忆力和奖励相关的区域。它会增加多巴胺的释放，从而导致愉悦感和成瘾性。

💪 **戒烟的挑战：** 戒烟是一个挑战，因为尼古丁会引起强烈的渴望和戒断症状。然而，通过使用科学工具和寻求支持，戒烟是可能的。

In this episode, I explain how nicotine impacts the brain and body, including its potent ability to enhance attention, focus, and alertness, increase blood pressure and metabolism and reduce appetite. I discuss nicotine’s ability to increase the action of neurochemicals, including dopamine, norepinephrine, and acetylcholine and activate sympathetic (alertness-promoting) neural circuits. I also discuss common nicotine delivery methods, such as cigarettes, vaping, dip, and snuff, and how they each create their own unique experience and how they, but not nicotine itself, cause cancer and other adverse health effects. I also explain science-based tools to permanently quit smoking cigarettes or vaping, including peer-reviewed clinical hypnosis tools, antidepressants, and alternative nicotine replacement (patches, lozenges, gums etc.). As nicotine is one of the most widely used substances with billions of users — most of whom report wanting to quit — this episode ought to be of interest to former/current nicotine users, those who want to quit smoking or vaping and/or those interested in learning the biology behind how nicotine impacts the brain and body.

For the full show notes, visit hubermanlab.com.

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Timestamps

(00:00:00) Nicotine

(00:03:41) Tool: Brief Daily Meditation & Focus

(00:05:59) The Arrow Model of Focus, Alpha GPC & Garlic Supplements

(00:10:05) Sponsor: LMNT

(00:14:35) Nicotine Effects vs. Methods of Delivery, Acetylcholine

(00:19:55) Where is Nicotine Found? Nicotinic Acetylcholine Receptors

(00:25:12) Nicotine & Effects on the Brain: Appetite, Dopamine & GABA

(00:29:37) Sponsor: AG1

(00:32:11) Nicotine, Acetylcholine & Attentional “Spotlighting”

(00:37:29) Nicotine, Norepinephrine & Alertness/Energy

(00:41:10) Nicotine & Effects on Appetite & Metabolism

(00:46:47) Nicotine & Effects on Body: Sympathetic Tone

(00:51:29) Nicotine & Cognitive Work vs. Physical Performance

(00:55:08) Nicotine Delivery Methods & Side Effects, Young People & Dependency

(00:58:35) Smoking, Vaping, Dipping & Snuffing: Carcinogens & Endothelial Cells

(01:02:34) Smoking, Vaping, Dipping & Snuffing: Negative Impacts on Lifespan & Health

(01:09:23) How to Quit Smoking, Nicotine Cravings & Withdrawal

(01:13:56) Vaping & Nicotine, Rates of Effect Onset, Dopamine, Addiction & Depression

(01:25:06) Tool: Quitting Smoking & Clinical Hypnosis, Reveri

(01:30:16) Bupropion (Wellbutrin) & Quitting Smoking

(01:36:24) Tool: A Nicotine Replacement Schedule to Quit Smoking, Nicotine Patch/Gum

(01:41:52) Tool: Biological Homeostasis & Nicotine Withdrawal, The “First Week” Strategy

(01:51:39) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter, Facebook

Title Card Photo Credit: Mike Blabac

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