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Controllable Surface Diffusion Generative Model for Neurodevelopmental Trajectories
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本文提出一种新型图扩散网络,用于模拟早产儿神经发育过程,并通过人类连接组项目数据验证,模型能准确模拟皮质形态变化,为认知和行为困难风险预测提供新方法。

arXiv:2508.03706v1 Announce Type: cross Abstract: Preterm birth disrupts the typical trajectory of cortical neurodevelopment, increasing the risk of cognitive and behavioral difficulties. However, outcomes vary widely, posing a significant challenge for early prediction. To address this, individualized simulation offers a promising solution by modeling subject-specific neurodevelopmental trajectories, enabling the identification of subtle deviations from normative patterns that might act as biomarkers of risk. While generative models have shown potential for simulating neurodevelopment, prior approaches often struggle to preserve subject-specific cortical folding patterns or to reproduce region-specific morphological variations. In this paper, we present a novel graph-diffusion network that supports controllable simulation of cortical maturation. Using cortical surface data from the developing Human Connectome Project (dHCP), we demonstrate that the model maintains subject-specific cortical morphology while modeling cortical maturation sufficiently well to fool an independently trained age regression network, achieving a prediction accuracy of $0.85 \pm 0.62$.

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早产儿神经发育 图扩散网络 皮质形态模拟 认知行为困难 风险预测
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