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LLM-Augmented Symptom Analysis for Cardiovascular Disease Risk Prediction: A Clinical NLP
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本研究提出一种基于LLM-augmented临床NLP的心血管疾病风险分层模型,通过心血管特定微调、基于提示的推理和实体感知推理等方法,有效提升了预测精度。评估结果显示,模型在MIMIC-III和CARDIO-NLP数据集上性能显著提高,对临床具有高相关性。

arXiv:2507.11052v1 Announce Type: cross Abstract: Timely identification and accurate risk stratification of cardiovascular disease (CVD) remain essential for reducing global mortality. While existing prediction models primarily leverage structured data, unstructured clinical notes contain valuable early indicators. This study introduces a novel LLM-augmented clinical NLP pipeline that employs domain-adapted large language models for symptom extraction, contextual reasoning, and correlation from free-text reports. Our approach integrates cardiovascular-specific fine-tuning, prompt-based inference, and entity-aware reasoning. Evaluations on MIMIC-III and CARDIO-NLP datasets demonstrate improved performance in precision, recall, F1-score, and AUROC, with high clinical relevance (kappa = 0.82) assessed by cardiologists. Challenges such as contextual hallucination, which occurs when plausible information contracts with provided source, and temporal ambiguity, which is related with models struggling with chronological ordering of events are addressed using prompt engineering and hybrid rule-based verification. This work underscores the potential of LLMs in clinical decision support systems (CDSS), advancing early warning systems and enhancing the translation of patient narratives into actionable risk assessments.

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LLM-augmented NLP 心血管疾病 风险分层 临床决策支持
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