保罗·奥菲特博士，儿科传染病专家，在《The Drive》节目中更新了当前所有SARS-CoV-2疫苗的情况，解释了关于mRNA疫苗的担忧并无根据，并分享了他对达到群体免疫的可能性和时间框架的看法。他还深入探讨了免疫学，解释了自然感染和疫苗接种的短期和长期免疫反应，以及这两种反应如何共同作用提供持久免疫力。此外，还讨论了新冠病毒起源的理论、新变种的可能影响，以及强生疫苗暂停的情况，并探讨了如何为未来新型病毒爆发做好准备。

🔍 保罗·奥菲特博士是FDA评估COVID-19疫苗委员会的成员，他在节目中提供了关于SARS-CoV-2疫苗的最新信息，包括疫苗的当前状态和策略。[详细内容]

🧬 他针对mRNA疫苗的担忧进行了回应，指出这些担忧并不成立，并解释了mRNA疫苗的工作原理和安全性。[详细内容]

🩺 奥菲特博士探讨了HIV疫苗研发失败如何帮助了COVID-19疫苗的开发，并讨论了SARS-CoV-2的变异能力及其对免疫和疫苗接种的意义。[详细内容]

🦠 他详细解释了SARS-CoV-2的短期和长期免疫反应如何协同作用，为人体提供持久的免疫力。[详细内容]

💉 讨论了暂停强生疫苗的决定，以及这一决定背后的脑血栓报告对疫苗信任度的影响。[详细内容]

🌍 奥菲特博士还讨论了群体免疫的定义，以及疫苗犹豫上升带来的担忧，预测了达到群体免疫的可能时间和未来儿童疫苗的展望。[详细内容]

🔬 最后，他探讨了SARS-CoV-2的起源理论，并就如何从错误中学习，为未来可能的流行病做好准备提出了建议。[详细内容]

Paul Offit is a pediatrician specializing in infectious diseases and an expert in virology and vaccine development. He currently serves on the FDA committee evaluating COVID-19 vaccines. In this episode, Paul’s second appearance on The Drive, he provides an update on all the SARS-CoV-2 vaccines currently deployed, explains why the concerns raised around the mRNA vaccines are not legitimate, and offers his view on the prospects and timeframe of reaching herd immunity. He also takes a deep dive into immunology, explaining the short-term and long-term immune response to both natural infection and vaccination and how these two can function together to provide durable immunity. Additionally, they discuss the theories on the origins of this virus, what impact the new COVID-19 variants might have, and the recent pausing of the J&J vaccine. Finally, they discuss how we can be better prepared for an inevitable future outbreak of a novel virus. This episode was originally recorded on April 14, 2021.

We discuss:

• Overview and current status of the SARS-CoV-2 vaccine strategies [4:10];

• Addressing concerns about mRNA vaccines [9:00];

• How the failure to make an effective HIV vaccine aided the development of a COVID-19 vaccine [16:45];

• Where SARS-CoV-2 falls on the spectrum of its ability to mutate and what that means for immunity and vaccination [21:30];

• How the combination of short-term and long-term immune response to SARS-CoV-2 work together to provide durable immunity [28:00];

• Importance of understanding relative vs. absolute risk reduction [38:15];

• Implications of pausing the J&J vaccine due to reports of blood clotting in the brain [42:45];

• What constitutes herd immunity and the concerns of rising vaccine hesitancy [47:45];

• When we might reach herd immunity, future vaccines for children, and long-term outlook for maintaining population immunity [58:45];

• Theories about the origins of SARS-CoV-2 [1:07:00];

• Preparing for the possibility of a future pandemic and how we can learn from our mistakes [1:10:40]; and

• More.

Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/pauloffit2  Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.