本期节目回顾了与Sarah Hallberg的对话（于2021年5月17日发布），她是一位在治疗代谢疾病方面挑战现状的杰出医生。Sarah Hallberg是Virta Health的医疗总监，她花了近二十年时间治疗肥胖和2型糖尿病患者。在本期节目中，Sarah分享了她如何通过研究和临床经验成为碳水化合物限制治疗2型糖尿病功效的坚定支持者。她挑战了关于膳食脂肪和碳水化合物对血浆脂肪酸和甘油三酯组成的作用的普遍观念。她还强调了理解代谢疾病的早期预测指标的重要性，并重点介绍了一种特定的脂肪酸作为最重要的早期预测指标。最后，她讨论了医生如何在未来个性化患者的代谢管理。

🤔 Sarah Hallberg是一位经验丰富的医生，她通过研究和临床经验，发现碳水化合物限制对逆转肥胖和2型糖尿病具有显著效果。她挑战了关于脂肪和碳水化合物对代谢指标影响的传统观点，强调了碳水化合物限制在治疗代谢疾病中的重要性。

📈 Sarah强调了早期识别代谢疾病的必要性，并指出棕榈油酸是重要的早期预测指标。她解释了代谢疾病的发生过程，以及如何通过早期干预来预防和控制疾病发展。

🧬 Sarah认为个性化代谢管理是未来趋势。她强调了不同个体对饮食和生活方式干预的反应差异，并呼吁医生根据患者的具体情况制定个性化的治疗方案。

💔 Sarah分享了她与肺癌抗争的个人故事，展现了她在面对疾病时的勇气和坚韧。她分享了她的治疗过程和感受，以及如何平衡工作和家庭，并最大限度地延长生存时间。

🙏 Sarah的故事鼓舞人心，她用自己的经历告诉我们，即使面对重大的挑战，我们也可以保持积极乐观的态度，并努力实现自己的目标。她的故事也提醒我们，早期预防和个性化治疗对于控制代谢疾病至关重要。

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Episode Description:

Today’s episode of The Drive is a rebroadcast of the conversation with Sarah Hallberg (released on May 17th, 2021). It's with great sadness that we report that Sarah recently lost her battle with lung cancer, and as such we've decided to republish her episode to honor her amazing work in challenging the status quo in the treatment of metabolic disease.

Sarah Hallberg was the Medical Director at Virta Health and a physician who spent nearly two decades treating patients with obesity and type 2 diabetes. In the first half of this episode, Sarah discusses how she became a huge believer in the efficacy of carbohydrate restriction for the treatment of type 2 diabetes through her research and clinical experience. Sarah challenges the common beliefs about the role of dietary fat and carbohydrate on the plasma makeup of fatty acids and triglycerides. She also expresses the importance of understanding early predictors of metabolic illness—highlighting one particular fatty acid as the most important early predictor—before finishing with a discussion about how doctors might be able to personalize patients’ metabolic management in the future. In the second half of this episode, Sarah tells the personal story of her own lung cancer diagnosis. She talks about dealing with her grief, deciding to continue her work while prioritizing her family, and how she devised a plan to extend her survival as long as possible. 

We discuss:

• How Sarah discovered the profound impact of carbohydrate restriction for reversing obesity and type 2 diabetes [2:00];
• Prediabetes and metabolic syndrome: prevalence, early signs, and the importance of treating early [14:45];
• Overview of fatty acids, how they are metabolized, and understanding what you see in a standard blood panel [28:00];
• The relationship between diet composition and metabolic markers [34:00];
• Why palmitoleic acid is such an important biomarker [47:00];
• The best early indicators of metabolic disease [58:45];
• Personalized management of metabolic illness [1:05:45];
• Sarah’s cancer diagnosis and the beginning of her journey [1:14:00];
• The emotional impact of a devastating diagnosis [1:26:00];
• Sarah’s plan to extend survival [1:35:30];
• Sarah’s aggressive treatment plan [1:46:15];
• Life-threatening complications and the return of her cancer [1:57:45];
• Sarah’s reflections on her approach to life with chronic cancer and balancing her time [2:09:45]; and
• More.

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