本文基于一项名为 SSC 的调查，对 2090 名服用过 SSRIs 的受访者进行了问卷调查，分析了 SSRIs 的有效性和不同类型 SSRIs 的差异性。调查结果显示，多数人认为 SSRIs 有效，但不同类型 SSRIs 的有效性存在差异，其中 Lexapro 的评分最高，Paxil 的评分最低，这可能与 Paxil 的副作用有关。

😊 **有效性评估：** 调查结果显示，多数人认为 SSRIs 有效，其中 21.4% 的受访者表示 SSRIs 使他们感觉好很多，41.4% 的受访者表示 SSRIs 使他们感觉稍微好一些。需要注意的是，这些数据包含安慰剂效应，因此不能完全代表 SSRIs 的真实效果。

🤔 **不同类型 SSRIs 的差异性：** 调查结果显示，不同类型 SSRIs 的有效性存在差异，其中 Lexapro 的评分最高，为 5.7 分，而 Paxil 的评分最低，为 4.6 分。其他 SSRIs（如 Zoloft、Prozac、Celexa）的评分则较为接近。

😔 **副作用的影响：** 调查结果显示，Paxil 的评分较低可能与它较高的副作用有关。调查中，受访者将副作用视为“负面效力”，因此 Paxil 的评分可能被副作用所影响。

📊 **调查结果与其他研究的对比：** 调查结果与 drugs.com 的评分结果高度一致，这表明该调查结果具有一定的可信度。

🧐 **进一步研究的方向：** 尽管该调查提供了有关 SSRIs 的一些有价值的信息，但仍需进一步研究以更全面地了解 SSRIs 的作用机制和不同类型 SSRIs 的差异性。

💡 **SSRIs 的选择：** 在选择 SSRIs 时，应考虑个人情况和药物的副作用。与医生进行充分的沟通，才能选择最适合自己的药物。

SSRIs are the most widely used class of psychiatric medications, helpful for depression, anxiety, OCD, panic, PTSD, anger, and certain personality disorders (Why should the same drug treat all these things? Great question!) They’ve been pretty thoroughly studied, but there’s still a lot we don’t understand about them.

The SSC Survey is less rigorous than most existing studies, but its many questions and very high sample size provide a different tool to investigate some of these issues. I asked fifteen questions about SSRIs on the most recent survey and received answers from 2,090 people who had been on SSRIs. The sample included people on all six major SSRIs, but there were too few people on fluvoxamine (15) to have reliable results, so it was not included in most comparisons. Here’s what we found:

1. Do SSRIs work?

People seem to think so:

Made me feel much worse: 6% Made me feel slightly worse: 7.4% No net change in how I felt: 23.7% Made me feel slightly better: 41.4% Made me feel much better: 21.4%

Of course, these statistics include the placebo effect and so cannot be taken entirely at face value.

2. Do some SSRIs work better than others?

I asked people to rate their experience with the medication, on a scale from 1 to 10. Here were the results:

Lexapro (356): 5.7 Zoloft (470): 5.6 Prozac (339): 5.5 Celexa (233): 5.4 Paxil (126): 4.6

Paxil differed significantly from the others; the others did not differ significantly among themselves. In a second question where participants were just asked to rate their SSRIs from -2 (“made me feel much worse”) to +2 (“made me feel much better”), the ranking was preserved, and Lexapro also separated from Celexa.

This ranking correlates at r = 0.98 (!?!) with my previous study of this taken from drugs.com ratings.

I don’t generally hear that Paxil is less effective than other SSRIs, but I have heard that it causes worse side effects. The survey question (probably wrongly) encouraged people to rate side effects as “negative efficacy”. My guess is that the difference here is mostly driven by side effects.