本期节目邀请了特拉维夫大学神经生物学教授奥德·雷卡维博士，他是基因遗传、经验如何塑造基因以及某些经验记忆如何通过基因传递给后代的专家。他探讨了挑战长期遗传继承理论的研究，以及这些发现与理解代谢、压力和创伤等关键生物和心理过程的相关性。他描述了对“获得性性状的遗传性”的科学探索历史，以及表观遗传学和 RNA 生物学如何解释某些基于经验的记忆的传递。他讨论了模式生物在科学研究中的重要性，并描述了他的工作，即压力源和记忆如何通过小 RNA 分子传递给多代后代，从而以有意义的方式影响他们的行为。自然与培育是一个经常被争论的话题；雷卡维博士的工作代表了我们对这场辩论以及遗传继承、大脑功能和进化的理解的根本转变。

👨‍🔬 雷卡维博士的研究挑战了长期以来关于遗传的传统理论，揭示了经验如何影响基因，甚至将某些经验记忆传递给后代。他深入探讨了“获得性性状的遗传性”这一概念，并解释了表观遗传学和 RNA 生物学在其中扮演的关键角色。

🧬 雷卡维博士的研究表明，环境压力和记忆可以通过小 RNA 分子传递给多代后代，从而影响后代的行为。这种跨代遗传机制挑战了传统的自然与培育的二元论，表明环境因素可以对基因表达产生持久的影响。

🔬 雷卡维博士的研究利用模式生物秀丽隐杆线虫进行实验，该生物易于研究，并具有明显的遗传特征。通过对秀丽隐杆线虫的研究，他发现某些经验记忆可以被编码到 RNA 分子中，并传递给后代，从而影响其行为和生存能力。

🧠 雷卡维博士的研究结果对我们理解大脑功能、遗传继承和进化具有重大意义。它表明，我们所经历的事情不仅会影响我们自己，还会影响我们的后代。这种跨代遗传机制为理解某些疾病的遗传易感性、人类行为的进化基础以及自然选择的过程提供了新的视角。

In this episode, my guest is Oded Rechavi, Ph.D., professor of neurobiology at Tel Aviv University and expert in how genes are inherited, how experiences shape genes and remarkably, how some memories of experiences can be passed via genes to offspring. We discuss his research challenging long-held tenets of genetic inheritance and the relevance of those findings to understanding key biological and psychological processes including metabolism, stress and trauma. He describes the history of the scientific exploration of the “heritability of acquired traits” and how epigenetics and RNA biology can account for some of the passage of certain experience-based memories. He discusses the importance of model organisms in scientific research and describes his work on how stressors and memories can be passed through small RNA molecules to multiple generations of offspring in ways that meaningfully affect their behavior. Nature vs. nurture is a commonly debated theme; Dr. Rechavi’s work represents a fundamental shift in our understanding of that debate, as well as genetic inheritance, brain function and evolution.

For the full show notes, visit hubermanlab.com.

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Timestamps

(00:00:00) Dr. Oded Rechavi

(00:02:25) Sponsor: LMNT

(00:06:04) DNA, RNA, Protein; Somatic vs. Germ Cells

(00:14:36) Lamarckian Evolution, Inheritance of Acquired Traits

(00:22:54) Paul Kammerer & Toad Morphology

(00:25:16) Sponsor: AG1

(00:30:06) James McConnell & Memory Transfer

(00:37:31) Weismann Barrier; Epigenetics 

(00:45:13) Epigenetic Reprogramming; Imprinted Genes 

(00:50:43) Nature vs. Nurture; Epigenetics & Offspring

(00:59:06) Generational Epigenetic Inheritance 

(01:10:20) Model Organisms, C. elegans

(01:21:50) C. elegans & Inheritance of Acquired Traits, Small RNAs

(01:26:02) RNA Interference, C. elegans & Virus Immunity

(01:34:13) RNA Amplification, Multi-Generational Effects

(01:38:41) Response Duration & Environment

(01:47:50) Generational Memory Transmission, RNA

(01:59:36) Germ Cells & Behavior; Body Cues

(02:04:48) Transmission of Sexual Choice

(02:11:22) Fertility & Human Disease; 3-Parent In Vitro Fertilization (IVF); RNA Testing

(02:17:56) Deliberate Cold Exposure, Learning & Memory

(02:29:26) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter

Title Card Photo Credit: Mike Blabac

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