本期播客邀请了华盛顿大学儿科助理教授Tommy Wood，探讨了与年龄相关的认知衰退以及如何通过干预措施来应对。Tommy结合其在F1赛车手方面的经验，强调了认知功能与适当的需求和训练之间的联系。节目深入探讨了痴呆症和神经退行性疾病的病理学，Tommy认为许多痴呆症可以通过生活方式的选择和营养状况来预防，并详细介绍了支持认知功能的干预措施和补充剂。此外，节目还全面概述了头部损伤，包括脑震荡和创伤性脑损伤（TBIs），讨论了症状、减轻损伤的方法以及长期管理。

🧠 Tommy Wood教授的研究重点在于脑损伤、生活方式选择和环境因素对脑健康、认知功能和慢性疾病的影响。他强调了认知功能与适当的需求和训练之间的联系，以及如何通过干预措施来应对与年龄相关的认知衰退。

🏎️ Tommy分享了F1赛车手作为在高认知需求下表现的模型的经验，以及如何提高多任务处理能力。他探讨了针对中年人群的认知衰退干预建议，并介绍了支持和改善认知功能的任务和活动。

🧠 节目深入探讨了阿尔茨海默病的神经病理学，包括淀粉样蛋白和tau蛋白的作用。Tommy认为痴呆症研究的资金应侧重于环境和生活方式相关的风险因素，并介绍了降低高半胱氨酸和增强omega-3脂肪酸的益处，以及支持认知功能的循证补充剂。

💪 节目还讨论了肌肉力量在预防和提高痴呆症生存率方面的作用。此外，节目还涵盖了头部损伤，比较了脑震荡与创伤性脑损伤（TBIs），讨论了减轻损伤、长期管理以及高压氧治疗的有效性。Tommy还推荐了有助于从TBI中恢复的补充剂，如肌酸、DHA和胆碱。

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Tommy Wood is an Assistant Professor of Pediatrics at the University of Washington, where he studies brain injury and how lifestyle choices and environmental factors contribute to brain health, cognitive function, and chronic disease. In this episode, Tommy delves into the complexities of age-related cognitive decline and explores interventions to counteract it. Drawing from his experience working with Formula 1 drivers, he highlights the connection between cognitive function and the right type of demands and training leading to improvement. Next, he explores the various theories on the different types of pathology in dementia and neurodegeneration. He makes the case that a large fraction of dementia is preventable through lifestyle choices and nutrient status, and provides an in-depth overview of interventions and supplements that support cognitive function. Finally, he provides a comprehensive overview of head injuries, including concussions and traumatic brain injuries (TBIs), discussing symptoms, how to mitigate damage following an incident, and long-term management.

We discuss:

Tommy’s professional work, unique skill sets, and interests [3:00]; Age-related decline in cognitive function and memory [5:45]; Improving brain function with the right level and type of demand [20:15]; Formula 1 as a model for how to perform under high cognitive demand and how to increase multitasking capacity [31:30]; Advice for the person reaching middle life looking to mitigate cognitive decline [37:45]; Tasks and activities that support and improve cognitive function [45:30]; Neuropathology of Alzheimer’s disease: exploring the role of amyloid and tau proteins [49:30]; Why Tommy believes dementia research funding should be focused on environmental and lifestyle-based risk factors [1:05:15]; Benefits of lowering homocysteine and boosting omega-3’s, and evidence-based supplements that support cognitive function [1:09:00]; A unifying theory of dementia [1:20:45]; How muscular strength can help with both the prevention and survivability of dementia [1:24:15]; Head injuries: comparing concussions against traumatic brain injuries (TBIs), mitigating the damage after an incident, and the long-term management of head injuries [1:29:15]; Is hyperbaric oxygen treatment helpful after a TBI? [1:45:45]; Supplements that aid recovery from a TBI: creatine, DHA, and choline [1:49:30]; Demands faced by F1 drivers, and testing interventions to improve their performance [1:57:30]; and More.

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