TechCrunch News 03月10日 03:13
Colossal CEO Ben Lamm says humanity has a ‘moral obligation’ to pursue de-extinction tech
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Colossal是一家致力于利用基因编辑技术复活灭绝物种的创业公司,其CEO Ben Lamm在SXSW大会上强调,公司并无意打造现实版的侏罗纪公园。Colossal的目标是复活渡渡鸟、袋狼(塔斯马尼亚虎)以及猛犸象等物种,并计划在2028年培育出猛犸象杂交后代,将其重新引入北极苔原栖息地。公司已获得数亿美元的风险投资,估值高达102亿美元。Colossal还专注于特定应用,包括尚未公布的第三家公司。Lamm认为,物种“重新野化”和碳封存蕴含着数十亿美元的商机。Colossal的近期项目包括基因编辑的“多毛小鼠”,该物种具有类似猛犸象的突变,展现出长而蓬松的黄褐色毛发。

🧬Colossal公司致力于利用基因编辑技术复活已灭绝物种,如猛犸象、渡渡鸟和袋狼,旨在恢复生态系统,并坚决否认会重现“侏罗纪公园”的场景。

💰Colossal公司获得了巨额投资,估值超过100亿美元,并拆分出专注于特定应用的公司,这表明投资者对其“复活”物种的理念和潜在商业价值充满信心。

🐭Colossal公司通过基因编辑技术创造出“多毛小鼠”,验证了其在猛犸象基因编辑方面的技术可行性,并展示了合成生物学在物种复活领域的应用前景。

🌱Colossal公司CEO Ben Lamm认为,合成生物学的发展将带来癌症治疗、海洋塑料清除和清洁水普及等突破,并预测人类将在未来20年内实现“长寿逃逸速度”,显著延长平均寿命。

The CEO of Colossal, a startup that aims to use genetic editing techniques to bring back extinct species, including the wooly mammoth, assured audiences at SXSW that the company has no plans to create a real-life Jurassic Park — lest there was any doubt.

“Modern conservation isn’t working […] and we’re gonna need a ‘de-extinction’ toolkit,” Colossal CEO Ben Lamm said during an onstage interview Sunday in Austin, responding to questions from actor and board member Joe Manganiello. “I think that we have a moral obligation and an ethical obligation to pursue technologies [that] undo some of the things that we [as a species] have done.”

Colossal is working to bring back the dodo bird and thylacine, commonly known as the Tasmanian tiger, well as the wooly mammoth, Lamm added. But the de-extinction of dinosaurs wouldn’t be possible due to the lack of usable sources of dinosaur DNA.

Dallas-based Colossal, founded in 2023 by Lamm and George Church, has stated that it wants to have woolly mammoth hybrid calves by 2028, which it hopes to reintroduce to the Arctic tundra habitat. The company is also leading a research project to release Tasmanian tiger joeys back to their original Tasmanian and broader Australian habitat after a period of captivity.

That vision has resonated with investors. Colossal has raised hundreds of millions of dollars in venture capital, and it’s currently valued at $10.2 billion.

Colossal has spun out two companies focused on specific applications, including a third that hasn’t yet been announced. Lamm also said he thinks there’s “billions of dollars” to be made from the “re-wilding” of species and carbon sequestration.

One of Colossal’s recent high-profile projects is the gene-edited “woolly mouse,” a mouse species with mutations inspired by woolly mammoths. The mice, which exhibit long, shaggy, tawny-toned fur, were developed using a mix of mammoth-like and known mouse hair-growth mutations.

Some experts have expressed skepticism of the new species, arguing that the experiment was more about mouse genetics than a breakthrough in de-extinction.

Lamm, however, said that the project validated Colossal’s work on wooly mammoth de-extinction.

“It showed us that, initially, our edits that we were making for the mammoth are the right edits,” Lamm said.

Colossal Biosciences – woolly mouseImage Credits:Colossal Biosciences

Lamm touched on AI during the interview, saying that he believes that the combination of access to computing, AI, and synthetic biology will be the most “dangerous” set of technologies the world has seen. But he also painted an idealistic picture of the future, predicting that synthetic biology advances in particular will lead to cures for cancer, means of removing plastics from the oceans, and the widespread availability of clean water.

“We will have true dominion over life, where we can eradicate species that are invasive or we can bring back lost species,” Lamm said, “and I think we’ll also have the ability to engineer plants — not just for food consumption, but you will be able to engineer plants with different types of proteins.”

Lamm also said that he anticipates humanity will “achieve longevity escape velocity” in the next 20 years, adding years to the average human life expectancy and making immortality a theoretical possibility.

Beyond human longevity, Lamm said de-extinction may require a “Manhattan Project-scale project” to back up endangered species specifically in “bio vaults” to create stem and egg cells. Lamm said he’s talked to “a country that seems excited about it” — without naming names.

On the subject of work with governments, Lamm mentioned that Colossal meets “quarterly” with U.S. government agencies and that the U.S. government has invested in Colossal, presumably via grants.

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Colossal 基因编辑 物种复活 合成生物学
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