Fortune | FORTUNE 2024年11月11日
Working out at these times of day could reduce your risk of colorectal cancer by 11%, new study says
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一项研究发现,每天早晚进行体育锻炼,例如早上8点和晚上6点左右,与结直肠癌风险降低11%相关,这超出了整体体育锻炼带来的益处。研究人员分析了英国生物样本库中超过86,000人的数据,发现早晚锻炼的人群结直肠癌风险降低。此外,持续一整天的体育活动也与风险降低6%相关,但其他时间段的锻炼效果不明显。研究表明,锻炼时间对降低结直肠癌风险至关重要,为制定更有针对性的预防策略提供了新思路。虽然研究样本量较大,但种族多样性有限,且未考虑运动类型和强度,未来还需要更多研究来证实这一发现。

⏰早晚锻炼降低结直肠癌风险:研究发现,每天早晚(约8点和6点)进行体育活动,与结直肠癌风险降低11%相关,这超出了整体体育活动的益处。

🚶持续全天活动也有一定效果:持续一整天的体育活动与结直肠癌风险降低6%相关,尤其对久坐人群效果更佳。

⚠️其他时间段锻炼效果不确定:研究发现,中午和夜间锻炼对降低结直肠癌风险没有显著效果,而仅在傍晚锻炼的数据则尚不确定。

🤔研究局限性:研究样本种族多样性有限,且仅观察了一周的运动数据,未来需要更多研究来验证结论,并考虑运动类型和强度等因素。

💪建议:适度增加日常活动量,例如爬楼梯代替坐电梯,并结合自身情况,咨询医生制定合适的运动计划。

Compared to other workout patterns studied, peak physical activity in both the morning and evening, around 8 a.m. and 6 p.m., was associated with an 11% lower risk of colorectal cancer “beyond the benefits of overall physical activity,” according to research published in September in the journal BMC Medicine.Researchers from institutions in Germany, France, Canada, and Spain used information from a health research database called the UK Biobank to assess the physical activity habits of more than 86,000 people aged 42 to 79, over half (56%) of whom were women. They wore accelerometers, devices that tracked their physical activity, on their dominant wrists for a week. The researchers noted these activity patterns among study participants: Continuous daylong activityActivity later in the day (6 p.m.)Early and late-day activity (8 a.m. and 6 p.m.)Activity in the middle of the day and during the nightDuring the median five-year follow-up period, more than 500 participants (0.6%) developed colorectal cancer. After accounting for other cancer risk factors including smoking, shift work, and family history of colorectal cancer, the research team found that people whose physical activity peaked both early and late in the day had an 11% reduced risk of colorectal cancer.People who were continuously physically active during the day showed a 6% lower risk. People who were active in the middle of the day and at night didn’t have a reduced risk, and data were inconclusive for those mostly active later in the day.“Our study highlights that not only is physical activity important for reducing colorectal cancer risk, but the timing of peak activity throughout the day could play a crucial role,” lead study investigator Dr. Michael Leitzmann, chair of the Department of Epidemiology and Preventive Medicine at the University of Regensburg in Germany, said in a WCRF news release. “By identifying specific times—early morning and late day—when physical activity is most beneficial, our findings open new avenues for targeted prevention strategies. “If confirmed by future research, this could provide a simple yet impactful way for individuals to further reduce their cancer risk through the timing of their exercise.”Sedentary people saw most benefit from all-day physical activityWhile morning and evening physical activity was most beneficial to study participants overall, continuous daylong activity most effectively reduced colorectal cancer risk among participants who reported more sedentary behavior.One possible explanation for this finding, the researchers noted, is that the more active subjects were already at a lower risk of developing cancer. Therefore, people who spend most of the day sitting down saw a greater health benefit from becoming more active.“Being physically active is one of our cancer prevention recommendations, and we know that this cuts cancer risk,” Helen Croker, PhD, WCRF assistant director of research and policy, said in the news release. “These intriguing new findings offer potential for developing more specific recommendations, including patterns and timing of physical activity, for reducing cancer risk. “This shows the vital importance of World Cancer Research Fund continuing to support research that expands our knowledge to inform cancer prevention going forward.”Despite the study’s large sample size, its racial and ethnic diversity is limited; 95% of UK Biobank subjects are white. In addition, this study didn’t consider activity type or intensity. Also, because participants wore accelerometers for only a week, that snapshot in time may not be indicative of their long-term behaviors.Any movement that uses your skeletal muscles and requires more energy than resting is considered physical activity, according to the National Cancer Institute. (Yes, doing household chores counts.)Tetra Images/Getty ImagesWhat counts as physical activity?The study results aren’t meant to suggest you have to hit the gym hard twice a day to lower your cancer risk. Simply incorporating more movement throughout your day—particularly if you have a job that keeps you sitting at a desk or behind a wheel—may help get you on your way. Swapping the elevator for the stairs, for example, is a start.Any movement that uses your skeletal muscles and requires more energy than resting is considered physical activity, according to the National Cancer Institute. (Yes, doing household chores counts.) To reduce the risk of chronic diseases including cancer, the Physical Activity Guidelines for Americans, championed by the Department of Health and Human Services, recommends adults do this much exercise weekly:150–300 minutes of moderately intense aerobic activity or 75–150 minutes of vigorous aerobic activity2 days of muscle-strengthening activitiesOlder adults should also include balance trainingWhether you want to sprinkle in brief walks here and there or take up kickboxing, discuss any mobility concerns you may have with your health care provider before switching up your workout routine.What’s my risk of getting colorectal cancer?About one in 23 men and one in 25 women will develop colorectal cancer, according to the American Cancer Society (ACS). The organization lists these among the risk factors for the disease:50+ years oldAlcohol useAmerican Indian, Alaskan Native, African American, or Ashkenazi Jewish ancestryColorectal polypsDiet high in red and processed meatsGallbladder removal (cholecystectomy)Inflammatory bowel diseaseOverweight or obesitySmokingType 2 diabetesMore than 53,000 people in the U.S. will die from colorectal cancer this year, the ACS estimates. It’s the third-leading cause of cancer-related deaths in men, fourth in women, and second for both sexes combined. The ACS recommends people at average risk of colorectal cancer start regular screenings at age 45.For more on colorectal cancer:Subscribe to Well Adjusted, our newsletter full of simple strategies to work smarter and live better, from the Fortune Well team. Sign up for free today.

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结直肠癌 体育锻炼 运动时间 健康风险 癌症预防
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